Spreading the tau
نویسندگان
چکیده
منابع مشابه
AD genetic risk factors and tau spreading
Development of tau pathology is associated with progressive neuronal loss and cognitive decline. In the brains of Alzheimer’s disease (AD) patients, tau pathology propagates according to an anatomically defined pattern with relatively uniform distribution, and contributes to cognitive decline in age-associated tauopathy (Braak and Braak, 1991; Saito et al., 2004). Recently, it has been revealed...
متن کاملIn Vivo Spreading of Tau Pathology
Recent findings have suggested that tau pathology may spread in the brain by a prion-like mechanism. In this issue of Neuron, de Calignon et al. (2012) recreated an early stage of neurofibrillary tangle pathology to show that tau aggregates initially generated in a circumscribed area spread throughout the brain and lead to neurodegeneration.
متن کاملTau Spreading Mechanisms; Implications for Dysfunctional Tauopathies
Tauopathies comprise a group of progressive age-associated neurodegenerative diseases where tau protein deposits are found as the predominant pathological signature (primary tauopathies) or in combination with the presence of other toxic aggregates (secondary tauopathies). In recent years, emerging evidence suggests that abnormal tau accumulation is mediated through spreading of seeds of the pr...
متن کاملReactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Pathological aggregation of tau is a hallmark of Alzheimer's disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy. Here, we show that microglia drive tau pathology in a cell-autonomous manner. First, tau hyperphosphorylation ...
متن کاملThe role of extracellular Tau in the spreading of neurofibrillary pathology
The microtubule-associated protein (MAP) tau plays a critical role in the pathogenesis of Alzheimer's disease (AD) and several related disorders collectively known as tauopathies. Development of tau pathology is associated with progressive neuronal loss and cognitive decline. In the brains of AD patients, tau pathology spreads following an anatomically defined pattern. Mounting evidence strongl...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2009
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2686